Cancer neuroscience: State of the field, emerging directions
The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …
during development, maintaining homeostasis, and promoting plasticity throughout life, the …
Pathogenesis underlying neurological manifestations of long COVID syndrome and potential therapeutics
The development of long-term symptoms of coronavirus disease 2019 (COVID-19) more
than four weeks after primary infection, termed “long COVID” or post-acute sequela of …
than four weeks after primary infection, termed “long COVID” or post-acute sequela of …
Electrical and synaptic integration of glioma into neural circuits
HS Venkatesh, W Morishita, AC Geraghty, D Silverbush… - Nature, 2019 - nature.com
High-grade gliomas are lethal brain cancers whose progression is robustly regulated by
neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but …
neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but …
Glioblastoma remodelling of human neural circuits decreases survival
Gliomas synaptically integrate into neural circuits,. Previous research has demonstrated
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc− is
implicated in numerous pathologies. Pharmacological agents that inhibit system xc− activity …
implicated in numerous pathologies. Pharmacological agents that inhibit system xc− activity …
Glutamatergic synaptic input to glioma cells drives brain tumour progression
A network of communicating tumour cells that is connected by tumour microtubes mediates
the progression of incurable gliomas. Moreover, neuronal activity can foster malignant …
the progression of incurable gliomas. Moreover, neuronal activity can foster malignant …
Reactive gliosis and the multicellular response to CNS damage and disease
The CNS is prone to heterogeneous insults of diverse etiologies that elicit multifaceted
responses. Acute and focal injuries trigger wound repair with tissue replacement. Diffuse …
responses. Acute and focal injuries trigger wound repair with tissue replacement. Diffuse …
The neuroscience of cancer
The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …
Parallel to roles in development, the nervous system is emerging as a critical regulator of …
Remote neuronal activity drives glioma progression through SEMA4F
The tumour microenvironment plays an essential role in malignancy, and neurons have
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …
Synaptic proximity enables NMDAR signalling to promote brain metastasis
Metastasis—the disseminated growth of tumours in distant organs—underlies cancer
mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and …
mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and …