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Small-cell lung cancer: what we know, what we need to know and the path forward
Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung
cancers and is pathologically, molecularly, biologically and clinically very different from other …
cancers and is pathologically, molecularly, biologically and clinically very different from other …
Small-cell lung cancer
The incidence and mortality of small-cell lung cancer worldwide make this disease a notable
health-care issue. Diagnosis relies on histology, with the use of immunohistochemical …
health-care issue. Diagnosis relies on histology, with the use of immunohistochemical …
[HTML][HTML] Somatostatin and somatostatin receptors in tumour biology
U Kumar - International Journal of Molecular Sciences, 2024 - mdpi.com
Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and
non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release …
non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release …
Cell and environment interactions in tumor microregions: the multicell spheroid model
RM Sutherland - Science, 1988 - science.org
Abnormal vascularization of malignant tumors is associated with the development of
microregions of heterogeneous cells and environments. Experimental models such as …
microregions of heterogeneous cells and environments. Experimental models such as …
Peptide-based drug-delivery systems in biotechnological applications: recent advances and perspectives
Peptides of natural and synthetic sources are compounds operating in a wide range of
biological interactions. They play a key role in biotechnological applications as both …
biological interactions. They play a key role in biotechnological applications as both …
Peptide receptors as molecular targets for cancer diagnosis and therapy
During the past decade, proof of the principle that peptide receptors can be used
successfully for in vivo targeting of human cancers has been provided. The molecular basis …
successfully for in vivo targeting of human cancers has been provided. The molecular basis …
Antimitotic drugs in the treatment of cancer
Cancer is a complex disease since it is adaptive in such a way that it can promote
proliferation and invasion by means of an overactive cell cycle and in turn cellular division …
proliferation and invasion by means of an overactive cell cycle and in turn cellular division …
[HTML][HTML] Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy
G protein–coupled receptors (GPCRs) are the largest gene family of cell membrane–
associated molecules mediating signal transmission, and their involvement in key …
associated molecules mediating signal transmission, and their involvement in key …
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
Human B cell stimulatory factor 2 (BSF-2) was originally charac-terized and isolated as a T
cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin …
cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin …
Growth factors and cancer
SA Aaronson - Science, 1991 - science.org
Signaling pathways that mediate the normal functions of growth factors are commonly
subverted in cancer. Oncogenes identified by a variety of approaches have been shown to …
subverted in cancer. Oncogenes identified by a variety of approaches have been shown to …