Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung
cancers and is pathologically, molecularly, biologically and clinically very different from other …

The incidence and mortality of small-cell lung cancer worldwide make this disease a notable
health-care issue. Diagnosis relies on histology, with the use of immunohistochemical …

Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and
non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release …

Abnormal vascularization of malignant tumors is associated with the development of
microregions of heterogeneous cells and environments. Experimental models such as …

Peptides of natural and synthetic sources are compounds operating in a wide range of
biological interactions. They play a key role in biotechnological applications as both …

During the past decade, proof of the principle that peptide receptors can be used
successfully for in vivo targeting of human cancers has been provided. The molecular basis …

Cancer is a complex disease since it is adaptive in such a way that it can promote
proliferation and invasion by means of an overactive cell cycle and in turn cellular division …

G protein–coupled receptors (GPCRs) are the largest gene family of cell membrane–
associated molecules mediating signal transmission, and their involvement in key …

Human B cell stimulatory factor 2 (BSF-2) was originally charac-terized and isolated as a T
cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin …

Signaling pathways that mediate the normal functions of growth factors are commonly
subverted in cancer. Oncogenes identified by a variety of approaches have been shown to …