Liver fibrosis is characterized by the excessive deposition and accumulation of extracellular
matrix components, mainly collagens, and occurs in response to a broad spectrum of …

Primary liver cancer is the sixth most common cancer and the third most common cause of
cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is a major histologic type …

Despite the remarkable success of immunotherapies over the past decade, their
effectiveness against triple-negative breast cancer (TNBC) is limited to a small subset of …

Hepatocellular carcinoma (HCC) is the most common type of primary hepatic carcinoma,
which is a growing public health problem worldwide. One of the main genetic alterations in …

Dysregulation of the transforming growth factor‐β (TGF‐β) signaling pathway regulates
cancer stem cells (CSCs) and drug sensitivity, whereas it remains largely unknown how …

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and it
usually occurs following chronic liver disease. Although some progress has been made in …

Simple Summary Aberrant Wnt/β-catenin signaling has been reported to play crucial role in
pathogenesis of hepatocellular carcinoma (HCC). In this review, we focus on the regulatory …

Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human
hepatocellular carcinoma (HCC). Comprehensive genomic analyses have revealed that …

Abstract Aims Sorafenib (Sora) represents one of the few effective drugs for the treatment of
advanced hepatocellular carcinoma (HCC), while resistance and cardiotoxicity limit its …

Background Hepatocellular carcinoma (HCC) is a principal type of liver cancer with high
incidence and mortality rates. Regorafenib is a novel oral multikinase inhibitor for second …