Repurposing of drugs as STAT3 inhibitors for cancer therapy
Drug repurposing is a valuable approach in delivering new cancer therapeutics rapidly into
the clinic. Existing safety and patient tolerability data for drugs already in clinical use …
the clinic. Existing safety and patient tolerability data for drugs already in clinical use …
[HTML][HTML] Potential of cucurbitacin as an anticancer drug
Y Li, Y Li, Y Yao, H Li, C Gao, C Sun… - Biomedicine & …, 2023 - Elsevier
Abstract In Chinese medicine, the Cucurbitaceae family contains many compounds known
as cucurbitacins, which have been categorized into 12 classes ranging from A to T and more …
as cucurbitacins, which have been categorized into 12 classes ranging from A to T and more …
STAT3 transcription factor as target for anti-cancer therapy
STATs constitute a large family of transcription activators and transducers of signals that
have an important role in many cell functions as regulation of proliferation and differentiation …
have an important role in many cell functions as regulation of proliferation and differentiation …
Small-molecule PD-L1 inhibitor BMS1166 abrogates the function of PD-L1 by blocking its ER export
FF Chen, Z Li, D Ma, Q Yu - Oncoimmunology, 2020 - Taylor & Francis
Therapeutic monoclonal antibodies against the PD-L1/PD-1 (programmed death ligand-
1/programmed cell death protein-1) axis have achieved great successes in cancer …
1/programmed cell death protein-1) axis have achieved great successes in cancer …
Advances in immunosuppressive agents based on signal pathway
Z Xu, M Chu - Frontiers in Pharmacology, 2022 - frontiersin.org
Immune abnormality involves in various diseases, such as infection, allergic diseases,
autoimmune diseases, as well as transplantation. Several signal pathways have been …
autoimmune diseases, as well as transplantation. Several signal pathways have been …