Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with
potential to provide greater clinical benefit to patients with advanced-stage cancer. In …

Cancer immunotherapy has experienced remarkable advances in recent years. Striking
clinical responses have been achieved for several types of solid cancers (eg melanoma …

Purpose Therapeutic prostate-specific antigen (PSA)–targeted poxviral vaccines for prostate
cancer have been well tolerated. PROSTVAC-VF treatment was evaluated for safety and for …

After Edward Jenner established human vaccination over 200 years ago, attenuated
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …

CD8+ CTL play important roles against malignancy in both active and passive
immunotherapy. Nonetheless, the success of antitumor CTL responses may be improved by …

Viruses have been engineered for cancer therapy in a variety of ways. Approaches include
non-replicating gene therapy vectors, cancer vaccines and oncolytic viruses, but the clinical …

Advances in basic immunology have led to an improved understanding of the interactions
between the immune system and tumours, generating renewed interest in approaches that …

Local radiation is an established therapy for human tumors. Radiation also has been shown
to alter the phenotype of target tissue, including gene products that may make tumor cells …

Concurrent with US Food and Drug Administration (FDA) approval of the first therapeutic
cancer vaccine, a wide spectrum of other cancer vaccine platforms that target a diverse …

Abstract In this White Paper, we discuss the current state of microbial cancer therapy. This
paper resulted from a meeting ('Microbial Based Cancer Therapy') at the US National …