Synaptic sabotage: How Tau and α-Synuclein undermine synaptic health
Synaptic dysfunction is one of the earliest cellular defects observed in Alzheimer's disease
(AD) and Parkinson's disease (PD), occurring before widespread protein aggregation …
(AD) and Parkinson's disease (PD), occurring before widespread protein aggregation …
FAM19A5 deficiency mitigates the Aβ plaque burden and improves cognition in mouse models of Alzheimer's disease
S Park, A Shahapal, S Yoo, H Kwak… - Experimental …, 2024 - pmc.ncbi.nlm.nih.gov
FAM19A5, a novel secretory protein highly expressed in the brain, is potentially associated
with the progression of Alzheimer's disease (AD). However, its role in the AD pathogenesis …
with the progression of Alzheimer's disease (AD). However, its role in the AD pathogenesis …
Partial FAM19A5 Deficiency in Mice Leads to Disrupted Spine Maturation, Hyperactivity, and an Altered Fear Response
A Shahapal, S Park, S Yoo, JI Hwang, JY Seong - bioRxiv, 2024 - biorxiv.org
The FAM19A5 polypeptide, encoded by the TAFA5 gene, is evolutionarily conserved among
vertebral species. This protein is predominantly expressed in the brain, highlighting its …
vertebral species. This protein is predominantly expressed in the brain, highlighting its …
[HTML][HTML] Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knockout, and LacZ knockin mice
H Kwak, EH Cho, EB Cho, YN Lee, A Shahapal… - Molecules and cells, 2024 - Elsevier
ABSTRACT FAM19A5 is a novel secretory protein expressed primarily in the brain.
However, a recent study reported that FAM19A5 is an adipocyte-derived adipokine that …
However, a recent study reported that FAM19A5 is an adipocyte-derived adipokine that …