Machine learning approaches to drug response prediction: challenges and recent progress
Cancer is a leading cause of death worldwide. Identifying the best treatment using
computational models to personalize drug response prediction holds great promise to …
computational models to personalize drug response prediction holds great promise to …
Non-coding RNAs in cancer: Platforms and strategies for investigating the genomic “dark matter”
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …
Reviving the transcriptome studies: an insight into the emergence of single-molecule transcriptome sequencing
Advances in transcriptomics have provided an exceptional opportunity to study functional
implications of the genetic variability. Technologies such as RNA-Seq have emerged as …
implications of the genetic variability. Technologies such as RNA-Seq have emerged as …
Single-cell RNA sequencing with spatial transcriptomics of cancer tissues
Single-cell RNA sequencing (RNA-seq) techniques can perform analysis of transcriptome at
the single-cell level and possess an unprecedented potential for exploring signatures …
the single-cell level and possess an unprecedented potential for exploring signatures …
[HTML][HTML] Unravelling glioblastoma heterogeneity by means of single-cell RNA sequencing
Glioblastoma (GBM) is the most invasive and deadliest brain cancer in adults. Its inherent
heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper …
heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper …
ACE2 and furin expressions in oral epithelial cells possibly facilitate COVID-19 infection via respiratory and fecal–oral routes
Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that mainly transfers from human to human via …
syndrome coronavirus 2 (SARS-CoV-2) that mainly transfers from human to human via …
Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in Southern China
and southeast Asia, which is characterized by a dense lymphocyte infiltration and a poor …
and southeast Asia, which is characterized by a dense lymphocyte infiltration and a poor …
Assessment of statistical methods from single cell, bulk RNA-seq, and metagenomics applied to microbiome data
Background The correct identification of differentially abundant microbial taxa between
experimental conditions is a methodological and computational challenge. Recent work has …
experimental conditions is a methodological and computational challenge. Recent work has …
Circulating biomarkers for glioma: a review
Accurate circulating biomarkers have potential clinical applications in population screening,
tumor subclassification, monitoring tumor status, and the delivery of individualized …
tumor subclassification, monitoring tumor status, and the delivery of individualized …
Platforms for single-cell collection and analysis
Single-cell analysis has become an established method to study cell heterogeneity and for
rare cell characterization. Despite the high cost and technical constraints, applications are …
rare cell characterization. Despite the high cost and technical constraints, applications are …