Multiprotein signalling networks create focal points of enzyme activity that disseminate the
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

A diffusion barrier at the transition zone enables the compartmentalization of signaling
molecules by cilia. The BBSome and the small guanosine triphosphatase Arl6, which …

Cytotoxic T lymphocytes (CTLs) use polarized secretion to rapidly destroy virally infected
and tumor cells. To understand the temporal relationships between key events leading to …

Hedgehog pathway components and select G protein-coupled receptors (GPCRs) localize
to the primary cilium, an organelle specialized for signal transduction. We investigated …

The centrosome is the main microtubule organization centre of animal cells. It is composed
of a centriole pair surrounded by pericentriolar material (PCM). Traditionally described as …

The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

As the main microtubule-organizing centre in animal cells, the centrosome has a
fundamental role in cell function. Surrounding the centrioles, the pericentriolar material …

In animal cells, the primary cilium transduces extracellular signals through signaling
receptors localized in the ciliary membrane, but how these ciliary membrane proteins are …

Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …