The TNF-α/TNFR2 pathway: targeting a brake to release the anti-tumor immune response
A Moatti, JL Cohen - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Newly discovered anti-cancer immunotherapies, such as immune checkpoint inhibitors and
chimeric antigen receptor T cells, focus on spurring the anti-tumor effector T cell (Teff) …
chimeric antigen receptor T cells, focus on spurring the anti-tumor effector T cell (Teff) …
TNFR2: Role in cancer immunology and immunotherapy
Immune checkpoint inhibitors (ICIs), including anti-CTLA-4 (cytotoxic T lymphocyte antigen-
4) and anti-PD-1/PD-L1 (programmed death-1/programmed death-ligand 1), represent a …
4) and anti-PD-1/PD-L1 (programmed death-1/programmed death-ligand 1), represent a …
The effects of TNF‐α/TNFR2 in regulatory T cells on the microenvironment and progression of gastric cancer
Y Qu, X Wang, S Bai, L Niu, G Zhao… - … journal of cancer, 2022 - Wiley Online Library
TNFR2+ regulatory T cells preferentially accumulate in the tumor microenvironment, express
high levels of immunosuppressive molecules and possess strong suppressive activity. Our …
high levels of immunosuppressive molecules and possess strong suppressive activity. Our …
[HTML][HTML] Targeting regulatory T cells in gastric cancer: Pathogenesis, immunotherapy, and prognosis
B Wang, Z Zhang, W Liu, B Tan - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Gastric cancer (GC) remains one of the most common malignancies worldwide. Despite
immune-checkpoint inhibitors (ICIs) has revolutionized cancer treatment and obtained …
immune-checkpoint inhibitors (ICIs) has revolutionized cancer treatment and obtained …
Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity
Z Jiang, H Zhu, P Wang, W Que, L Zhong, XK Li… - MedComm, 2022 - Wiley Online Library
Abstract CD4+ CD25+ regulatory T cells (Tregs), a subpopulation of naturally CD4+ T cells
that characteristically express transcription factor Forkhead box P3 (FOXP3), play a pivotal …
that characteristically express transcription factor Forkhead box P3 (FOXP3), play a pivotal …
Targeting TNFR2: A novel breakthrough in the treatment of cancer
M Li, X Zhang, X Bai, T Liang - Frontiers in Oncology, 2022 - frontiersin.org
Tumor necrosis factor (TNF) receptor type II (TNFR2) is expressed in various tumor cells and
some immune cells, such as regulatory T cells and myeloid-derived suppressing cells …
some immune cells, such as regulatory T cells and myeloid-derived suppressing cells …