Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors
A Gashler, VP Sukhatme - Progress in nucleic acid research and molecular …, 1995 - Elsevier
Publisher Summary This chapter discusses the early growth response protein (Egr) gene
family and its most extensively characterized member, Egr-1, first identified as an immediate …
family and its most extensively characterized member, Egr-1, first identified as an immediate …
Early growth response 1—a transcription factor in the crossfire of signal transduction cascades
JI Pagel, E Deindl - 2011 - nopr.niscpr.res.in
Early growth response-1 (Egr-1) is a Cys2-His2-type zinc-finger transcription factor. A broad
range of extracellular stimuli is capable of activating Egr-1, thus mediating growth …
range of extracellular stimuli is capable of activating Egr-1, thus mediating growth …
Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8
Differentiation mechanisms and inflammatory functions of neutrophils and macrophages are
usually studied by genetic and biochemical approaches that require costly breeding and …
usually studied by genetic and biochemical approaches that require costly breeding and …
The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage
HQ Nguyen, B Hoffman-Liebermann, DA Liebermann - Cell, 1993 - cell.com
We have isoiated cDNA clones of myelold differentiation primary response (MyD) genes,
activated in the absence of de novo protein synthesis following induction for differentiation …
activated in the absence of de novo protein synthesis following induction for differentiation …
Identification of NAB1, a repressor of NGFI-A-and Krox20-mediated transcription.
MW Russo, BR Sevetson… - Proceedings of the …, 1995 - National Acad Sciences
NGFI-A (also called Egr1, Zif268, or Krox24) and the closely related proteins Krox20, NGFI-
C, and Egr3 are zinc-finger transcription factors encoded by immediate-early genes which …
C, and Egr3 are zinc-finger transcription factors encoded by immediate-early genes which …
Genomics and proteomics analysis of acetaminophen toxicity in mouse liver
SU Ruepp, RP Tonge, J Shaw, N Wallis… - Toxicological …, 2002 - academic.oup.com
Overdose of acetaminophen (APAP) causes severe centrilobular hepatic necrosis in
humans and experimental animals. Here, to explore its mechanism, we administered APAP …
humans and experimental animals. Here, to explore its mechanism, we administered APAP …
Ionizing radiation activates transcription of the EGR1 gene via CArG elements.
The present studies have examined the effects of ionizing radiation on control of the early
growth response 1 (EGR1) gene. Exposure of human HL-525 cells to x-rays was associated …
growth response 1 (EGR1) gene. Exposure of human HL-525 cells to x-rays was associated …
Lactic acid delays the inflammatory response of human monocytes
K Peter, M Rehli, K Singer, K Renner-Sattler… - Biochemical and …, 2015 - Elsevier
Lactic acid (LA) accumulates under inflammatory conditions, eg in wounds or tumors, and
influences local immune cell functions. We previously noted inhibitory effects of LA on …
influences local immune cell functions. We previously noted inhibitory effects of LA on …
The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair
Alveolar macrophages are the most abundant macrophages in the healthy lung where they
play key roles in homeostasis and immune surveillance against airborne pathogens. Tissue …
play key roles in homeostasis and immune surveillance against airborne pathogens. Tissue …
Characterization of the human PPARα promoter: identification of a functional nuclear receptor response element
PPARα is a nuclear receptor that controls lipid and glucose metabolism and exerts
antiinflammatory activities. The factors regulating human PPARα (hPPARα) gene expression …
antiinflammatory activities. The factors regulating human PPARα (hPPARα) gene expression …