Mammalian phospholipase D: Function, and therapeutics
Despite being discovered over 60 years ago, the precise role of phospholipase D (PLD) is
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
Functions and pathophysiological roles of phospholipase D in the brain
J Klein - Journal of neurochemistry, 2005 - Wiley Online Library
Ten years after the isoforms of mammalian phospholipase D (PLD), PLD1 and 2, were
cloned, their roles in the brain remain speculative but several lines of evidence now …
cloned, their roles in the brain remain speculative but several lines of evidence now …
Benzo [a] pyrene exposure induces anxiety-like behaviors in the mice through brain metabolic alterations
F Li, L **e, Q **ao, J Li, H Zhong, X Xu, J Tu… - Science of The Total …, 2024 - Elsevier
The deleterious health impacts of polycyclic aromatic hydrocarbons (PAHs) on the
population have been extensively substantiated and acknowledged. Mounting evidence …
population have been extensively substantiated and acknowledged. Mounting evidence …
Cytotoxicity of short-chain alcohols
RC Baker, RE Kramer - Annual review of pharmacology and …, 1999 - annualreviews.org
▪ Abstract Ethanol and other short-chain alcohols elicit a number of cellular responses that
are potentially cytotoxic and, to some extent, independent of cell type. Aberrations in …
are potentially cytotoxic and, to some extent, independent of cell type. Aberrations in …
Pharmacology of inositol trisphosphate receptors
In almost all cells, cytosolic Ca 2+ is a crucial intracellular messenger, regulating many
cellular processes. In non-excitable as well as in some excitable cells, Ca 2+ release from …
cellular processes. In non-excitable as well as in some excitable cells, Ca 2+ release from …
Structural and functional insight into a new emerging target IP3R in cancer
H Ismatullah, I Jabeen, YS Kiani - Journal of Biomolecular …, 2024 - Taylor & Francis
Calcium signaling has been identified as an important phenomenon in a plethora of cellular
processes. Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) are ER-residing intracellular …
processes. Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) are ER-residing intracellular …
Effects of ethanol on calcium homeostasis in the nervous system: implications for astrocytes
MC Catlin, M Guizzetti, LG Costa - Molecular neurobiology, 1999 - Springer
Ethanol is a major health concern, with neurotoxicity occurring after both in utero exposure
and adult alcohol abuse. Despite a large amount of research, the mechanism (s) underlying …
and adult alcohol abuse. Despite a large amount of research, the mechanism (s) underlying …
Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal‐Associated Loss of Neuron‐Specific Nuclear Protein …
AR Reynolds, MA Saunders… - Alcoholism: Clinical …, 2016 - Wiley Online Library
Background Prior studies demonstrate that ethanol (EtOH) exposure induces the release of
intracellular calcium (CA 2+) in modulation of γ‐aminobutyric acid‐ergic tone and produces …
intracellular calcium (CA 2+) in modulation of γ‐aminobutyric acid‐ergic tone and produces …
ethanol impairs phospholipase D signaling in astrocytes
U Burkhardt, J Klein - Molecular aspects of alcohol and nutrition, 2016 - Elsevier
Phospholipase D (PLD) is a central enzyme in the growth factor signaling pathway. In the
presence of ethanol, PLDs are able to catalyze a unique reaction: the …
presence of ethanol, PLDs are able to catalyze a unique reaction: the …
Phosphatidylethanol; clinical significance and biochemical basis
A Varga, K Moller, P Hansson, S Aradottir… - New and Upcoming …, 2001 - Springer
As shown in figure 1, ethanol can be metabolized by oxidative and nonoxidative pathways
(Lieber, 1995). In the oxidative pathway, ethanol is converted to acetal-dehyde through the …
(Lieber, 1995). In the oxidative pathway, ethanol is converted to acetal-dehyde through the …