Metagenomic sequencing for infectious disease diagnostics is an important tool that holds
promise for use in the clinical laboratory. Challenges for implementation so far include high …

The belief that, for the individual patient, the benefit of prompt and continued use of
antimicrobials outweighs any potential harm is a significant barrier to improved stewardship …

MicrobiomeAnalyst is an easy-to-use, web-based platform for comprehensive analysis of
common data outputs generated from current microbiome studies. It enables researchers …

Manipulation of the gut microbiota via fecal microbiota transplantation (FMT) has shown
clinical promise in diseases such as recurrent Clostridioides difficile infection (rCDI) …

Background & Aims Fecal microbiota transplantation (FMT) is a highly effective therapy for
recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria …

Dysbiosis of the gut microbiome has been associated with the pathogenesis of colorectal
cancer (CRC). We profiled the microbiome of gut mucosal tissues from 18 CRC patients and …

Small proteins are traditionally overlooked due to computational and experimental
difficulties in detecting them. To systematically identify small proteins, we carried out a …

Blood circulates throughout the human body and contains molecules drawn from virtually
every tissue, including the microbes and viruses which colonize the body. Through massive …

A comprehensive evaluation of every patient with a bloodstream infection includes an
attempt to identify the infectious source. Pathogens can originate from various places, such …

Accumulating evidence supports the high prevalence of co-infections among Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients, and their potential to worsen …