New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …

Oxygen is vital for life as it is required for many different enzymatic reactions involved in
intermediate metabolism and xenobiotic biotransformation. Moreover, oxygen consumption …

Cadmium (Cd) is a toxic environmental pollutant and induces toxic effects to organism.
Nevertheless, the mechanism of Cd-induced toxicity in swine remains obscure. To explore …

Objective Mitochondrial dysfunction, oxidative stress and nucleus pulposus (NP) cell
apoptosis are important contributors to the development and pathogenesis of intervertebral …

Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the
human lifespan that can increase the risk of low back pain. More clarification of the …

Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that
can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy …

Mesenchymal stem cell (MSCs)‐based therapies have shown a promised result for
intervertebral disc degeneration (IVDD) treatment. However, its molecular mechanisms …

Objective This paper aims to provide a comprehensive review of the changing role of
transforming growth factor-β (TGF-β) signaling in intervertebral disc (IVD) health and …

Highlights●H 2 S production was impaired in db/db mice and streptozotocin-induced
diabetic mice.●CSE knockout exacerbated diabetic cardiomyopathy in streptozotocin …

Excess iron has been reported to lead to osteoblastic cell damage, which is a crucial
pathogenesis of iron overload‐related osteoporosis. However, the cytotoxic mechanisms …