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Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …
Exploiting innate immunity for cancer immunotherapy
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …
However, most of these immunomodulatory strategies focus on harnessing adaptive …
A researcher's guide to preclinical mouse NASH models
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
[HTML][HTML] The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …
for end-stage liver diseases with no available therapies. Dysregulated immune responses …
Metabolic reprogramming in the tumor microenvironment of liver cancer
J Lin, D Rao, M Zhang, Q Gao - Journal of hematology & oncology, 2024 - Springer
The liver is essential for metabolic homeostasis. The onset of liver cancer is often
accompanied by dysregulated liver function, leading to metabolic rearrangements …
accompanied by dysregulated liver function, leading to metabolic rearrangements …
GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p/MARCH7/NLRP3 axis-mediated pyroptosis
T Chen, Y Meng, Z Zhou, H Li, L Wan, A Kang… - Cell Death & …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is characterised by hepatic steatosis, inflammation,
and insulin resistance. The role of long noncoding RNA (lncRNA)-regulated pyroptosis in …
and insulin resistance. The role of long noncoding RNA (lncRNA)-regulated pyroptosis in …
Molecular and immune landscape of hepatocellular carcinoma to guide therapeutic decision-making
Liver cancer, primarily HCC, exhibits highly heterogeneous histological and molecular
aberrations across tumors and within individual tumor nodules. Such intertumor and …
aberrations across tumors and within individual tumor nodules. Such intertumor and …
Phenotypes of metabolic dysfunction–associated steatotic liver disease–associated hepatocellular carcinoma
Hepatocellular carcinoma (HCC) typically develops as a consequence of liver cirrhosis, but
HCC epidemiology has evolved drastically in recent years. Metabolic dysfunction …
HCC epidemiology has evolved drastically in recent years. Metabolic dysfunction …
[HTML][HTML] Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
Metformin, as the preferred antihyperglycemic drug for type 2 diabetes, has been found to
have a significant effect in inhibiting tumor growth in recent years. However, metformin alone …
have a significant effect in inhibiting tumor growth in recent years. However, metformin alone …