Cell death by apoptosis and permanent cell cycle arrest by senescence serve as barriers to
the development of cancer. Chemotherapeutic agents not only induce apoptosis, they can …

Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

The MCL1 gene is frequently amplified in cancer and codes for the antiapoptotic protein
myeloid cell leukemia 1 (MCL1), which confers resistance to the current standard of care …

Simple Summary Hepatocellular carcinoma (HCC) is the most frequent primitive cancer of
the liver, accounting for 90% of all recorded cases. HCC is the third most common cause of …

The removal of cells by apoptosis is an essential process regulating tissue homeostasis.
Cancer cells acquire the ability to circumvent apoptosis and survive in an unphysiological …

Background Hepatocellular carcinoma (HCC) is a principal type of liver cancer with high
incidence and mortality rates. Regorafenib is a novel oral multikinase inhibitor for second …

Simple Summary Patients with unresectable hepatocellular carcinoma (HCC), the most
common primary tumor of the liver, have poor prognosis and are increasing worldwide. The …

Breast cancer (BC) remains a significant health burden worldwide, necessitating the
development of innovative therapeutic strategies. The B-cell lymphoma 2 (Bcl-2) family …

Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic
agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during …

Mitochondria participate in the progression of hepatocellular carcinoma (HCC) by modifying
processes including but not limited to redox homeostasis, metabolism, and the cell death …