Proline is a non-essential amino acid with key roles in protein structure/function and
maintenance of cellular redox homeostasis. It is available from dietary sources, generated …

Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ), a
transformation product of tyre-derived 6-PPD, has been frequently detected in different …

The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can
convert somatic differentiated cells into pluripotent stem cells in a process known as …

The extracellular matrix (ECM), composed of interlinked proteins outside of cells, is an
important component of the human body that helps maintain tissue architecture and cellular …

Liver fibrosis is associated with increased mortality and morbidity. However, there is not
effective treatment so far. Vinpocetine (Vinpo) is a synthetic derivative of vinca alkaloid …

Diacerein is an interleukin (IL)-1β inhibitor approved for osteoarthritis. This study aimed to
investigate the potential anti-fibrotic effect of diacerein against bile duct ligation (BDL) …

Fibrosis can affect any organ, resulting in the loss of tissue architecture and function with
often life-threatening consequences. Pathologically, fibrosis is characterised by the …

Background and Objectives: Metabolic-dysfunction-associated steatotic liver disease or
MASLD is the main cause of chronic liver diseases in children, and it is estimated to affect …

Aim Men are more susceptible to liver fibrosis (LF) than women. However, the underlying
molecular mechanism, especially the role of estrogen/estrogen receptor (ER) activation in …

Nanomaterials (NMs) can be produced in plenty of variants posing several challenges for
NM hazard and risk assessment. Metabolomic profiling of NM-treated cells and tissues …