Oxygen toxicity: cellular mechanisms in normobaric hyperoxia

R Alva, M Mirza, A Baiton, L Lazuran… - Cell Biology and …, 2023 - Springer
In clinical settings, oxygen therapy is administered to preterm neonates and to adults with
acute and chronic conditions such as COVID-19, pulmonary fibrosis, sepsis, cardiac arrest …

[HTML][HTML] Pathogenesis of bronchopulmonary dysplasia: role of oxidative stress from 'Omics' studies

A Kimble, ME Robbins, M Perez - Antioxidants, 2022 - mdpi.com
Bronchopulmonary dysplasia (BPD) remains the most common respiratory complication of
prematurity as younger and smaller infants are surviving beyond the immediate neonatal …

[HTML][HTML] Role of myeloperoxidase, oxidative stress, and inflammation in bronchopulmonary dysplasia

TJ Wu, X **g, M Teng, KA Pritchard Jr, BW Day… - Antioxidants, 2024 - mdpi.com
Bronchopulmonary dysplasia (BPD) is a lung complication of premature births. The leading
causes of BPD are oxidative stress (OS) from oxygen treatment, infection or inflammation …

Remarkable sex-specific differences at single-cell resolution in neonatal hyperoxic lung injury

A Cantu, MC Gutierrez, X Dong… - … of Physiology-Lung …, 2023 - journals.physiology.org
Exposure to supraphysiological concentrations of oxygen (hyperoxia) predisposes to
bronchopulmonary dysplasia (BPD), which is characterized by abnormal alveolarization and …

Toxicoepigenetics and environmental health: challenges and opportunities

LK Svoboda, BPU Perera, RK Morgan… - Chemical research in …, 2022 - ACS Publications
The rapidly growing field of toxicoepigenetics seeks to understand how toxicant exposures
interact with the epigenome to influence disease risk. Toxicoepigenetics is a promising field …

Moving bronchopulmonary dysplasia research from the bedside to the bench

M Gilfillan, V Bhandari - American Journal of Physiology …, 2022 - journals.physiology.org
Although advances in the respiratory management of extremely preterm infants have led to
improvements in survival, this progress has not yet extended to a reduction in the incidence …

Down-regulation of CXXC5 de-represses MYCL1 to promote hepatic stellate cell activation

X Wu, W Dong, M Kong, H Ren, J Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Liver fibrosis is mediated by myofibroblasts, a specialized cell type involved in wound
healing and extracellular matrix production. Hepatic stellate cells (HSC) are the major …

Epigenetic modifications in the development of bronchopulmonary dysplasia: a review

L Wang, J **ao, B Zhang, A Hou - Pediatric Research, 2024 - nature.com
While perinatal medicine advancements have bolstered survival outcomes for premature
infants, bronchopulmonary dysplasia (BPD) continues to threaten their long-term health …

Effect of sex chromosomes versus hormones in neonatal lung injury

SL Grimm, X Dong, Y Zhang, AF Carisey… - JCI …, 2021 - pmc.ncbi.nlm.nih.gov
The main mechanisms underlying sexually dimorphic outcomes in neonatal lung injury are
unknown. We tested the hypothesis that hormone-or sex chromosome–mediated …

Choline kinase alpha is a novel transcriptional target of the Brg1 in hepatocyte: implication in liver regeneration

M Kong, W Dong, H Xu, Z Fan, X Miao… - Frontiers in Cell and …, 2021 - frontiersin.org
Liver regeneration is a key compensatory process in response to liver injury serving to
contain damages and to rescue liver functions. Hepatocytes, having temporarily exited the …