Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

Importance Survival from sepsis has improved in recent years, resulting in an increasing
number of patients who have survived sepsis treatment. Current sepsis guidelines do not …

Background Septic shock is the most severe form of sepsis, in which profound underlying
abnormalities in circulatory and cellular/metabolic parameters lead to substantially …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

The nervous system regulates immunity and inflammation. The molecular detection of
pathogen fragments, cytokines, and other immune molecules by sensory neurons generates …

Trained immunity refers to a hyperresponsive functional state of the innate immune system,
which is induced by certain stimuli, such as infections or vaccination. Trained immunity plays …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies,
variable pathogenesis and diverse outcomes. However, these heterogeneities are not …

Sepsis is a systemic inflammatory response induced by an infection, leading to organ
dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were …

Sepsis-associated encephalopathy (SAE) is a significant clinical issue that is associated
with increased mortality and cost of health care. Dexmedetomidine, an α2 adrenoceptor …