The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism

C Wiest, F Torrecillos, A Pogosyan, M Bange… - Elife, 2023 - elifesciences.org
Periodic features of neural time-series data, such as local field potentials (LFPs), are often
quantified using power spectra. While the aperiodic exponent of spectra is typically …

[HTML][HTML] Perspectives of implementation of closed-loop deep brain stimulation: from neurological to psychiatric disorders

S Groppa, G Gonzalez-Escamilla… - Stereotactic and …, 2024 - karger.com
Background: Deep brain stimulation (DBS) is a highly efficient, evidence-based therapy to
alleviate symptoms and improve quality of life in movement disorders such as Parkinson's …

Oscillatory beta dynamics inform biomarker-driven treatment optimization for Parkinson's disease

EM Radcliffe, AJ Baumgartner… - Journal of …, 2023 - journals.physiology.org
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons and dysregulation of the basal ganglia. Cardinal motor symptoms …

Bursting with potential: how sensorimotor beta bursts develop from infancy to adulthood

H Rayson, MJ Szul, P El-Khoueiry, R Debnath… - Journal of …, 2023 - jneurosci.org
Beta activity is thought to play a critical role in sensorimotor processes. However, little is
known about how activity in this frequency band develops. Here, we investigated the …

Diverse beta burst waveform motifs characterize movement-related cortical dynamics

MJ Szul, S Papadopoulos, S Alavizadeh… - Progress in …, 2023 - Elsevier
Classical analyses of induced, frequency-specific neural activity typically average band-
limited power over trials. More recently, it has become widely appreciated that in individual …

Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control

M Bange, G Gonzalez-Escamilla, DM Herz… - Nature …, 2024 - nature.com
Increasing evidence suggests a considerable role of pre-movement beta bursts for motor
control and its impairment in Parkinson's disease. However, whether beta bursts occur …

Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease

MC Vinding, J Waldthaler, A Eriksson… - npj Parkinson's …, 2024 - nature.com
Parkinson's disease (PD) is associated with changes in neural activity in the sensorimotor
alpha and beta bands. Using magnetoencephalography (MEG), we investigated the role of …

[HTML][HTML] Evoked resonant neural activity in subthalamic local field potentials reflects basal ganglia network dynamics

C Wiest, S He, B Duchet, A Pogosyan, M Benjaber… - Neurobiology of …, 2023 - Elsevier
Evoked resonant neural activity (ERNA) is induced by subthalamic deep brain stimulation
(DBS) and was recently suggested as a marker of lead placement and contact selection in …

Controlling clinical states governed by different temporal dynamics with closed-loop deep brain stimulation: a principled framework

G Tinkhauser, EM Moraud - Frontiers in neuroscience, 2021 - frontiersin.org
Closed-loop strategies for deep brain stimulation (DBS) are paving the way for improving the
efficacy of existing neuromodulation therapies across neurological disorders. Unlike …

[HTML][HTML] Sub-harmonic entrainment of cortical gamma oscillations to deep brain stimulation in Parkinson's disease: Model based predictions and validation in three …

JJ Sermon, M Olaru, J Anso, S Cernera, S Little… - Brain stimulation, 2023 - Elsevier
Objectives The exact mechanisms of deep brain stimulation (DBS) are still an active area of
investigation, in spite of its clinical successes. This is due in part to the lack of understanding …