More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now
known to represent a distinct member of the IFN family and plays critical roles not only in …

The SOCS family of proteins are negative-feedback inhibitors of signalling induced by
cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by …

Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

Cancers | Free Full-Text | Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between
Obesity and Inflammation—Driven Liver and Colorectal Cancers Next Article in Journal Effects …

The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of
signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified …

Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening
infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic …

Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a
critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from …

Interferon-γ is a cytokine whose biological activity is conventionally associated with
cytostatic/cytotoxic and antitumor mechanisms during cell-mediated adaptive immune …