GFAP in health and disease

J Middeldorp, EM Hol - Progress in neurobiology, 2011 - Elsevier
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

Stem cells therapy for spinal cord injury

M Gazdic, V Volarevic, CR Harrell… - International journal of …, 2018 - mdpi.com
Spinal cord injury (SCI), a serious public health issue, most likely occurs in previously
healthy young adults. Current therapeutic strategies for SCI includes surgical …

[HTML][HTML] Stem cells for spinal cord repair

F Barnabé-Heider, J Frisén - Cell stem cell, 2008 - cell.com
Spinal cord injury typically results in permanent disability. Many studies have indicated that
transplantation of several different types of stem cells promotes functional recovery in animal …

Review of transplantation of neural stem/progenitor cells for spinal cord injury

AJ Mothe, CH Tator - International Journal of Developmental Neuroscience, 2013 - Elsevier
Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy …

Neural stem cells in the adult spinal cord

H Sabelström, M Stenudd, J Frisén - Experimental neurology, 2014 - Elsevier
Spinal cord injury results in cell loss, disruption of neural circuitry and chronic functional
impairment. Several different cell types generate progeny in response to injury, which …

Endogenous neural stem cell responses to stroke and spinal cord injury

CA Grégoire, BL Goldenstein, EM Floriddia… - Glia, 2015 - Wiley Online Library
Stroke and spinal cord injury (SCI) are among the most frequent causes of central nervous
system (CNS) dysfunction, affecting millions of people worldwide each year. The personal …

The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain

M Defaye, MC Iftinca, VM Gadotti, L Basso… - The Journal of clinical …, 2022 - jci.org
The anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase known for its oncogenic
potential that is involved in the development of the peripheral and central nervous system …

Decellularized scaffolds in regenerative medicine

Y Yu, A Alkhawaji, Y Ding, J Mei - Oncotarget, 2016 - pmc.ncbi.nlm.nih.gov
Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure.
Yet, the clinical application is limited by the shortage of donor organs and the need for …

Activated spinal cord ependymal stem cells rescue neurological function

V Moreno-Manzano, FJ Rodríguez-Jiménez… - Stem …, 2009 - academic.oup.com
Spinal cord injury (SCI) is a major cause of paralysis. Currently, there are no effective
therapies to reverse this disabling condition. The presence of ependymal stem/progenitor …

An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury

AR Albors, GA Singer, E Llorens-Bobadilla, J Frisen… - Developmental cell, 2023 - cell.com
The adult spinal cord stem cell potential resides within the ependymal cell population and
declines with age. Ependymal cells are, however, heterogeneous, and the biological …