Abstract Angiotensin (Ang)‐converting enzyme (ACE) 2 cleaves Ang‐II into the vasodilator
peptide Ang‐(1–7), thus acting as a pivotal element in balancing the local effects of these …

Apelin is a vasoactive peptide and is an endogenous ligand for APJ receptors, which are
widely expressed in blood vessels, heart, and cardiovascular regulatory regions of the brain …

Background—Apelin is among the most potent stimulators of cardiac contractility known.
However, no physiological or pathological role for apelin–angiotensin receptor-like 1 (APJ) …

Background—Apelin has been shown ex vivo to be a potent cardiac inotrope. This study
was undertaken to evaluate the in vivo effects of apelin on cardiac function in native and …

Obesity is associated with insulin resistance and type 2 diabetes; molecular mechanisms
that promote energy expenditure can be utilized for effective therapy. Src-associated in …

The apelin peptide is the endogenous ligand for the apelin G protein-coupled receptor. The
distribution of the apelin peptides and receptor are widespread in the central nervous …

Background: Apelin, the novel endogenous ligand for the G‐protein‐coupled receptor APJ,
has shown positive inotropic, vasodilatory and diuretic properties in animal studies …

Apelin is a novel peptide that acts through the APJ receptor, sharing similarities with the
angiotensin II–angiotensin II type 1 receptor pathway. It is a peripheral vasodilator, powerful …

Apelin is an endogenous ligand of G protein-coupled receptor APJ. It is extensively
expressed in many tissues such as heart, liver, and kidney, especially in lung tissue. A …

Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …