Spermatogenesis is supported by intricate crosstalk between Sertoli cells and germ cells
including spermatogonia, spermatocytes, haploid spermatids, and spermatozoa, which …

Simple Summary The unique characteristics of tumor energy metabolism (highly dependent
on aerobic glycolysis, namely, the Warburg effect) make it an interesting and attractive target …

Although cisplatin‐based neoadjuvant chemotherapy is an efficient therapy approach for
triple‐negative breast cancer (TNBC), it has dismal prognosis and modestly improved …

SIRT6 is an important histone modifying protein that regulates DNA repair, telomere
maintenance, energy metabolism, and target gene expression. Recently SIRT6 has been …

The relative contribution of mitochondrial respiration and subsequent energy production in
malignant cells has remained controversial to date. Enhanced aerobic glycolysis and …

Multi-drug resistance (MDR) of tumor is a major cause of chemotherapy failure. In this study,
a pH-sensitive graft copolymer, poly (β-amino ester)-g-β-cyclodextrin (PBAE-g-β-CD), was …

SIRT3 is involved in aging-related diseases including cancer, but its role in prostate cancer
and detailed regulatory function are not known. We found that SIRT3 was moderately down …

Combination therapy has been regarded as a potent strategy to overcome multidrug
resistance (MDR). In this study, we adopt Adjudin (ADD), a mitochondria inhibitor, and …

Herein, a small library of Pt (IV) prodrugs based on cisplatin and chemosensitizer adjudin
(ADD) were explored for efficient cisplatin resistant triple-negative breast cancer (TNBC) …

Photocatalysis is a powerful tool in modern organic synthesis, however, it has not been
applied to the synthesis of covalent organic frameworks (COFs), even in synthetic cascade …