Simple Summary Immunotherapies have revolutionized the field of cancer therapeutics, yet
a substantial subset of patients fail to respond. Recent efforts have focused on identifying …

Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

The tumor-associated vasculature imposes major structural and biochemical barriers to the
infiltration of effector T cells and effective tumor control. Correlations between stimulator of …

Immunotherapy has had a tremendous impact on cancer treatment in the past decade, with
hitherto unseen responses at advanced and metastatic stages of the disease. However, the …

KRAS-LKB1 (KL) mutant lung cancers silence STING owing to intrinsic mitochondrial
dysfunction, resulting in T cell exclusion and resistance to programmed cell death (ligand) 1 …

Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host
immune system and evade the cycle of immune recognition and destruction. Here, we …

Previous studies have developed vascularized tumor spheroid models to demonstrate the
impact of intravascular flow on tumor progression and treatment. However, these models …

Several methods have been developed for generating 3D, in vitro, organ-on-chip models of
human vasculature to study vascular function, transport, and tissue engineering. However …

The DNA sensor cGAS (cyclic GMP-AMP synthase) and its adaptor protein STING
(Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or …

This review describes recent research that has advanced our understanding of the role of
immune cells in the tumor microenvironment (TME) using advanced 3D in vitro models and …