Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
Advancing the understanding of autism disease mechanisms through genetics
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …
fueled remarkable advances in our understanding of its potential neurobiological …
Developmental and epileptic encephalopathies: what we do and do not know
Developmental encephalopathies, including intellectual disability and autistic spectrum
disorder, are frequently associated with infant epilepsy. Epileptic encephalopathy is used to …
disorder, are frequently associated with infant epilepsy. Epileptic encephalopathy is used to …
Dendritic spines: Revisiting the physiological role
Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …
Dendritic structural plasticity and neuropsychiatric disease
The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …
and refined throughout development and into adulthood. Evidence from human and animal …
[HTML][HTML] Neural stem cells: generating and regenerating the brain
One of the landmark events of the past 25 years in neuroscience research was the
establishment of neural stem cells (NSCs) as a life-long source of neurons and glia, a …
establishment of neural stem cells (NSCs) as a life-long source of neurons and glia, a …
Dendritic spines: the locus of structural and functional plasticity
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …
changed dramatically the rate of progress towards the understanding of the complex …
The promises and challenges of human brain organoids as models of neuropsychiatric disease
Neuropsychiatric disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ)
and bipolar disorder (BPD) are of great societal and medical importance, but the complexity …
and bipolar disorder (BPD) are of great societal and medical importance, but the complexity …
Cyclin-dependent kinase-like 5 deficiency disorder: clinical review
Abstract Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a
developmental encephalopathy caused by pathogenic variants in the gene CDKL5. This …
developmental encephalopathy caused by pathogenic variants in the gene CDKL5. This …
Induced pluripotent stem cells: the new patient?
Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …
chronic and age-associated disorders, particularly of the cardiovascular, neural and …