An updated review on diverse range of biological activities of 1, 2, 4-triazole derivatives: Insight into structure activity relationship

O Gupta, T Pradhan, G Chawla - Journal of Molecular Structure, 2023 - Elsevier
Abstract Since its discovery 1, 2, 4-triazole ring has emerged as a prominent heterocyclic
scaffold in medicinal chemistry. It possesses a wide spectrum of biological activities such as …

Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond

L Ravindar, SA Hasbullah, KP Rakesh… - European Journal of …, 2024 - Elsevier
Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds
that appear as a significant assembly motif for develo** new drug entities. Aminoquinoline …

1, 3, 5‐Triazine: A versatile pharmacophore with diverse biological activities

S Singh, MK Mandal, A Masih, A Saha… - Archiv der …, 2021 - Wiley Online Library
Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to
their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer …

Antitumor activity of s-triazine derivatives: A systematic review

Q Dai, Q Sun, X Ouyang, J Liu, L **, A Liu, B He, T Fan… - Molecules, 2023 - mdpi.com
1, 3, 5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen
heterocyclic compounds that play an important role in anticancer drug design and …

Membrane-active substituted triazines as antibacterial agents against Staphylococcus aureus with potential for low drug resistance and broad activity

S Gupta, K Paul - European Journal of Medicinal Chemistry, 2023 - Elsevier
A library of new naphthalimide–triazine analogues was synthesized as broad-spectrum
antibacterial agents to overcome drug resistance. Bioactivity assay reveals that derivative …

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)-s-triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling …

I Shawish, A Barakat, A Aldalbahi, AM Malebari… - ACS …, 2022 - ACS Publications
Here, we synthesized a newseries of mono-and bis (dimethylpyrazolyl)-s-triazine
derivatives. The synthetic methodology involved the reaction of different mono-and …

Recent advances in the biological activity of s-triazine core compounds

D Maliszewski, D Drozdowska - Pharmaceuticals, 2022 - mdpi.com
An effective strategy for successful chemotherapy relies on creating compounds with high
selectivity against cancer cells compared to normal cells and relatively low cytotoxicity. One …

Novel sulfonamide–triazine hybrid derivatives: docking, synthesis, and biological evaluation as anticancer agents

MA Alelaimat, MA Al-Sha'er, HA Basheer - ACS omega, 2023 - ACS Publications
The biological benefits of trisubstituted 1, 3, 5-triazine derivatives include their ability to
reduce inflammation and fight cancer. A unique series of sulfonamide–triazine hybrid …

Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships

R Pal, G Teli, G Swamy Purawarga Matada… - …, 2023 - Wiley Online Library
Cancer is a wide collection of diseases and among the numerous pathways involved in
cancer pathogenesis, pathway involving epidermal growth factor receptor (EGFR) is one of …

Functionalized triazines and tetrazines: Synthesis and applications

J Mondal, A Sivaramakrishna - Topics in Current Chemistry, 2022 - Springer
The molecules possessing triazine and tetrazine moieties belong to a special class of
heterocyclic compounds. Both triazines and tetrazines are building blocks and have …