Background: SET and MYND domain-containing protein 2 (SMYD2) is a lysine
methyltransferase for histone H3, p53 and Rb and inhibits their transactivation activities. In …

The aryl hydrocarbon receptor (AhR) is a ubiquitously expressed ligand-activated
transcription factor. While initially identified as an environmental sensor, this receptor has …

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although
several clinical characteristics can be associated with worse prognosis, more robust …

Protein lysine methyltransferases have recently emerged as a new target class for the
development of inhibitors that modulate gene transcription or signaling pathways. SET and …

MTSS1 is a ubiquitously expressed intracellular protein known mainly for its involvement in
basic cellular processes, such as the regulation of actin organization and membrane …

HtrA1 appears to be involved in several physiological processes as well as in the
pathogenesis of conditions such as Alzheimer's disease and osteoarthritis. It has also been …

Characterization of lysine methylation has proven challenging despite its importance in
biological processes such as gene transcription, protein turnover, and cytoskeletal …

Background Osteosarcoma is a malignant bone tumor that typically occurs in adolescents or
children under 20 years of age. Develo** efficient clinical prognostic markers is crucial for …

Background Non-metastatic locally advanced breast carcinoma (LABC) treatment involves
neoadjuvant chemotherapy (NCT). We evaluated the association of clinical–pathological …

A Crohn's-like lymphoid reaction (CLR) is observed in about 15% of colorectal cancer (CRC)
patients and is associated with favourable outcomes. To identify the immune targets …