Immunological aspects of necrotizing enterocolitis models: a review

L Blum, D Vincent, M Boettcher, J Knopf - Frontiers in Immunology, 2024 - frontiersin.org
Necrotizing enterocolitis (NEC) is one of the most devasting diseases affecting preterm
neonates. However, despite a lot of research, NEC's pathogenesis remains unclear. It is …

The emerging role of neutrophilic extracellular traps in intestinal disease

F Chen, Y Liu, Y Shi, J Zhang, X Liu, Z Liu, J Lv, Y Leng - Gut Pathogens, 2022 - Springer
Neutrophil extracellular traps (NETs) are extracellular reticular fibrillar structures composed
of DNA, histones, granulins and cytoplasmic proteins that are delivered externally by …

The emerging role of neutrophil extracellular traps in ulcerative colitis

D Long, C Mao, Y Xu, Y Zhu - Frontiers in Immunology, 2024 - frontiersin.org
Ulcerative colitis (UC) is characterized by chronic non-recessive inflammation of the
intestinal mucosa involving both innate and adaptive immune responses. Currently, new …

Netting gut disease: Neutrophil extracellular trap in intestinal pathology

K Chen, LH Shao, F Wang, XF Shen… - Oxidative Medicine …, 2021 - Wiley Online Library
Many gut disease etiologies are attributed to the presence of robust inflammatory cell
recruitment. The recruitment of neutrophils plays a vital role in inflammatory infiltration …

Early antibiotic exposure alters intestinal development and increases susceptibility to necrotizing enterocolitis: a mechanistic study

H Chaaban, MM Patel, K Burge, JV Eckert, C Lupu… - Microorganisms, 2022 - mdpi.com
Increasing evidence suggests that prolonged antibiotic therapy in preterm infants is
associated with increased mortality and morbidities, such as necrotizing enterocolitis (NEC) …

The role of neutrophil extracellular traps in necrotizing enterocolitis

M Klinke, H Chaaban, M Boettcher - Frontiers in Pediatrics, 2023 - frontiersin.org
Necrotizing enterocolitis (NEC) continues to be one of the most common causes of mortality
and morbidity in preterm infants. Although not fully elucidated, studies suggest that …

Advances in our understanding of the molecular pathogenesis of necrotizing enterocolitis

X Cai, A Golubkova, CJ Hunter - BMC pediatrics, 2022 - Springer
Necrotizing enterocolitis (NEC) is a multifactorial and complex disease. Our knowledge of
the cellular and genetic basis of NEC have expanded considerably as new molecular …

High-dimensional mass cytometry reveals systemic and local immune signatures in necrotizing enterocolitis

Y Liu, J Zhou, B Chen, X Liu, Y Cai, W Liu… - Frontiers in …, 2023 - frontiersin.org
Objective Patients with necrotizing enterocolitis display severe gastrointestinal
complications of prematurity, but the mechanism driving this clinical profile remains …

Neutrophil extracellular traps in urinary tract infection

K Krivošíková, N Šupčíková, A Gaál Kovalčíková… - Frontiers in …, 2023 - frontiersin.org
Background Urinary tract infections (UTI) are common types of bacterial infection in children.
UTI treatment is aimed to prevent complications including hypertension, proteinuria, and …

NETworking for Health and in Disease: Neutrophil Extracellular Traps in Pediatric Surgical Care

M Dölling, M Herrmann, M Boettcher - Children, 2024 - mdpi.com
This comprehensive review examines the role of Neutrophil Extracellular Traps (NETs) in
pediatric surgery. Focusing on NET formation, functions, and implications, this study …