Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota

AE Lindell, M Zimmermann-Kogadeeva… - Nature Reviews …, 2022‏ - nature.com
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

Inflammatory breast cancer biology: the tumour microenvironment is key

B Lim, WA Woodward, X Wang, JM Reuben… - Nature Reviews …, 2018‏ - nature.com
Inflammatory breast cancer (IBC) is a rare and aggressive disease that accounts for~ 2–4%
of all breast cancers. However, despite its low incidence rate, IBC is responsible for 7–10 …

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

EFSA Panel on Food Contact Materials … - EFSA …, 2023‏ - Wiley Online Library
In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body
weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the …

A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

NG Khan, J Correia, D Adiga, PS Rai… - … Science and Pollution …, 2021‏ - Springer
Abstract Bisphenol A [BPA;(CH 3) 2 C (C 6 H 4 OH) 2] is a synthetic chemical used as a
precursor material for the manufacturing of plastics and resins. It gained attention due to its …

The endocrine disruptor bisphenol A (BPA) exerts a wide range of effects in carcinogenesis and response to therapy

SA Hafezi, WM Abdel-Rahman - Current molecular …, 2019‏ - ingentaconnect.com
Background: Bisphenol A (BPA) is a synthetic plasticizer that is commonly used in the
production of polycarbonate plastics and epoxy resins. Human exposure occurs when BPA …

[HTML][HTML] ERK is a pivotal player of chemo-immune-resistance in cancer

IC Salaroglio, E Mungo, E Gazzano, J Kopecka… - International journal of …, 2019‏ - mdpi.com
The extracellular signal-related kinases (ERKs) act as pleiotropic molecules in tumors,
where they activate pro-survival pathways leading to cell proliferation and migration, as well …

[HTML][HTML] Adverse (geno) toxic effects of bisphenol A and its analogues in hepatic 3D cell model

M Sendra, M Štampar, K Fras, B Novoa… - Environment …, 2023‏ - Elsevier
Bisphenol A (BPA) is one of the most widely used and versatile chemical compounds in
polymer additives and epoxy resins for manufacturing a range of products for human …

[HTML][HTML] Cellular and physiological mechanisms of halogenated and organophosphorus flame retardant toxicity

L Khani, L Martin, Ł Pułaski - Science of the Total Environment, 2023‏ - Elsevier
Flame retardants (FRs) are chemical substances used to inhibit the spread of fire in
numerous industrial applications, and their abundance in modern manufactured products in …

[HTML][HTML] Bisphenol A promotes the progression of colon cancer through dual-targeting of NADPH oxidase and mitochondrial electron-transport chain to produce ROS …

T **a, J Guo, B Zhang, C Song, Q Zhao… - Frontiers in …, 2022‏ - frontiersin.org
Bisphenol A (BPA) is a high-production-volume industrial chemical. Despite recent research
conducted on its carcinogenicity, its role in the development of colon cancer (CC) has been …

Exploring the molecular mechanism of targeted extraction of novel flavonoid components in licorice using natural deep eutectic solvent

Y Hu, Z Zheng, D Zhai, J Lai, P Liang, Z Wang… - Journal of Molecular …, 2024‏ - Elsevier
In the previous study of our research group, it was found that choline chloride (ChCl)-glycolic
acid (GA) deep eutectic solvent (DES), as a green solvent, has good solubility for licorice …