Nicotinamide mononucleotide (NMN), the direct precursor of nicotinamide adenine
dinucleotide (NAD+), is involved in the regulation of many physiological and metabolic …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting both
upper and lower motor neurons. While there have been many potential factors implicated for …

Abnormal NAD+ signaling has been implicated in axonal degeneration in diabetic
peripheral neuropathy (DPN). We hypothesized that supplementing NAD+ precursors could …

Background: Blood biomarkers are crucial for the diagnosis and therapy of Alzheimer's
disease (AD). Energy metabolism disturbances are closely related to AD. However, research …

NAD+ plays a pivotal role in energy metabolism and adaptation to external stimuli and
stressful conditions. A significant reduction in intracellular NAD+ levels is associated with …

Nicotinamide mononucleotide adenylyl transferases 2 (NMNAT2) is a crucial nicotinamide
adenine dinucleotide (NAD)-synthesizing enzyme essential for neuronal health. In the …

Neurons are highly asymmetric post-mitotic cells whose processes extend long distances to
facilitate communication. Consequently, they encounter the complex problem of maintaining …

Nicotinamide adenine dinucleotide (NAD) is a redox cofactor and a coenzyme essential for
axonal health and neuronal survival. Increasing NAD levels has been suggested to be a …