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The emerging and diverse roles of bis (monoacylglycero) phosphate lipids in cellular physiology and disease
MR Showalter, AL Berg, A Nagourney, H Heil… - International Journal of …, 2020 - mdpi.com
Although understudied relative to many phospholipids, accumulating evidence suggests that
bis (monoacylglycero) phosphate (BMP) is an important class of regulatory lipid that plays …
bis (monoacylglycero) phosphate (BMP) is an important class of regulatory lipid that plays …
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic risk factors
for Parkinson's disease (PD). Increased LRRK2 kinase activity is thought to impair lysosomal …
for Parkinson's disease (PD). Increased LRRK2 kinase activity is thought to impair lysosomal …
[HTML][HTML] Acid sphingomyelinase, a lysosomal and secretory phospholipase C, is key for cellular phospholipid catabolism
B Breiden, K Sandhoff - International journal of molecular sciences, 2021 - mdpi.com
Here, we present the main features of human acid sphingomyelinase (ASM), its
biosynthesis, processing and intracellular trafficking, its structure, its broad substrate …
biosynthesis, processing and intracellular trafficking, its structure, its broad substrate …
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Abstract Bis (monoacylglycero) phosphate (BMP) is a major phospholipid constituent of
intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation …
intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation …
Bis (monoacylglycero) phosphate, an important actor in the host endocytic machinery hijacked by SARS-CoV-2 and related viruses
C Luquain-Costaz, M Rabia, F Hullin-Matsuda, I Delton - Biochimie, 2020 - Elsevier
Viruses, including the novel coronavirus SARS-CoV-2, redirect infected cell metabolism to
their own purposes. After binding to its receptor angiotensin-converting enzyme 2 (ACE2) on …
their own purposes. After binding to its receptor angiotensin-converting enzyme 2 (ACE2) on …
[HTML][HTML] Supplementation with a specific combination of metabolic cofactors ameliorates non-alcoholic fatty liver disease, hepatic fibrosis, and insulin resistance in …
S Quesada-Vázquez, M Colom-Pellicer… - Nutrients, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have
emerged as the leading causes of chronic liver disease in the world. Obesity, insulin …
emerged as the leading causes of chronic liver disease in the world. Obesity, insulin …