Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …

The nervous and immune systems are intricately linked. Although psychological stress is
known to modulate immune function, mechanistic pathways linking stress networks in the …

Neurons have recently emerged as essential cellular constituents of the tumour
microenvironment, and their activity has been shown to increase the growth of a diverse …

Over the past 10 years, the development and convergence of microbial opsin engineering,
modular genetic methods for cell-type targeting and optical strategies for guiding light …

An increasingly powerful approach for studying brain circuits relies on targeting genetically
encoded sensors and effectors to specific cell types. However, current approaches for this …

The incorporation of new information into the hippocampal network is likely to be
constrained by its innate architecture and internally generated activity patterns. However, the …

Active neurons exert a mitogenic effect on normal neural precursor and oligodendroglial
precursor cells, the putative cellular origins of high-grade glioma (HGG). By using …

Introduction Myelin is formed by mature oligodendrocytes to facilitate fast propagation of
action potentials in axons. Small changes in myelin thickness can confer substantial …

Brain function depends on simultaneous electrical, chemical and mechanical signaling at
the cellular level. This multiplicity has confounded efforts to simultaneously measure or …