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Optogenetics for light control of biological systems
Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
Integration of optogenetics with complementary methodologies in systems neuroscience
Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …
Brain motor and fear circuits regulate leukocytes during acute stress
The nervous and immune systems are intricately linked. Although psychological stress is
known to modulate immune function, mechanistic pathways linking stress networks in the …
known to modulate immune function, mechanistic pathways linking stress networks in the …
Climbing fibers provide essential instructive signals for associative learning
Supervised learning depends on instructive signals that shape the output of neural circuits to
support learned changes in behavior. Climbing fiber (CF) inputs to the cerebellar cortex …
support learned changes in behavior. Climbing fiber (CF) inputs to the cerebellar cortex …
Lipidome atlas of the adult human brain
Lipids are the most abundant but poorly explored components of the human brain. Here, we
present a lipidome map of the human brain comprising 75 regions, including 52 neocortical …
present a lipidome map of the human brain comprising 75 regions, including 52 neocortical …
NF1 mutation drives neuronal activity-dependent initiation of optic glioma
Neurons have recently emerged as essential cellular constituents of the tumour
microenvironment, and their activity has been shown to increase the growth of a diverse …
microenvironment, and their activity has been shown to increase the growth of a diverse …
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis
The incorporation of new information into the hippocampal network is likely to be
constrained by its innate architecture and internally generated activity patterns. However, the …
constrained by its innate architecture and internally generated activity patterns. However, the …
Optogenetics: 10 years of microbial opsins in neuroscience
Over the past 10 years, the development and convergence of microbial opsin engineering,
modular genetic methods for cell-type targeting and optical strategies for guiding light …
modular genetic methods for cell-type targeting and optical strategies for guiding light …
[HTML][HTML] Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance
An increasingly powerful approach for studying brain circuits relies on targeting genetically
encoded sensors and effectors to specific cell types. However, current approaches for this …
encoded sensors and effectors to specific cell types. However, current approaches for this …
[HTML][HTML] Neuronal activity promotes glioma growth through neuroligin-3 secretion
Active neurons exert a mitogenic effect on normal neural precursor and oligodendroglial
precursor cells, the putative cellular origins of high-grade glioma (HGG). By using …
precursor cells, the putative cellular origins of high-grade glioma (HGG). By using …