A PON for all seasons: comparing paraoxonase enzyme substrates, activity and action including the role of PON3 in health and disease
Paraoxonases (PONs) are a family of hydrolytic enzymes consisting of three members,
PON1, PON2, and PON3, located on human chromosome 7. Identifying the physiological …
PON1, PON2, and PON3, located on human chromosome 7. Identifying the physiological …
The impact of dyslipidemia and oxidative stress on vasoactive mediators in patients with renal dysfunction
M Jabarpour, N Rashtchizadeh, H Argani… - … Urology and Nephrology, 2019 - Springer
Hyperlipidemia and oxidative stress are indispensable features of chronic kidney disease
(CKD) that favor the development of atherogenic plaques and cardiovascular disease …
(CKD) that favor the development of atherogenic plaques and cardiovascular disease …
Myeloperoxidase-induced modification of HDL by isolevuglandins inhibits paraoxonase-1 activity
Reduced activity of paraoxonase 1 (PON1), a high-density lipoprotein (HDL)-associated
enzyme, has been implicated in the development of atherosclerosis. Post-translational …
enzyme, has been implicated in the development of atherosclerosis. Post-translational …
HDL in COVID-19 patients: Evidence from an Italian cross-sectional study
B Papotti, C Macchi, C Favero, S Iodice… - Journal of clinical …, 2021 - mdpi.com
A number of studies have highlighted important alterations of the lipid profile in COVID-19
patients. Besides the well-known atheroprotective function, HDL displays anti-inflammatory …
patients. Besides the well-known atheroprotective function, HDL displays anti-inflammatory …
Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease
MV Milaciu, ȘC Vesa, IC Bocșan… - Journal of clinical …, 2019 - mdpi.com
Background: Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver
diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with …
diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with …
Cardioprotective role for paraoxonase-1 in chronic kidney disease
Paraoxonase-1 (PON-1) is a hydrolytic enzyme associated with HDL, contributing to its anti-
inflammatory, antioxidant, and anti-atherogenic properties. Deficiencies in PON-1 activity …
inflammatory, antioxidant, and anti-atherogenic properties. Deficiencies in PON-1 activity …
Understanding the heterogeneity and dysfunction of HDL in chronic kidney disease: insights from recent reviews
Z Xu, S Yang, L Cui - BMC nephrology, 2024 - Springer
Chronic kidney disease (CKD) is a complex disease that affects the global population's
health, with dyslipidemia being one of its major complications. High density lipoprotein …
health, with dyslipidemia being one of its major complications. High density lipoprotein …
Paraoxonases at the Heart of Neurological Disorders
Paraoxonase enzymes serve as an important physiological redox system that participates in
the protection against cellular injury caused by oxidative stress. The PON enzymes family …
the protection against cellular injury caused by oxidative stress. The PON enzymes family …
Paraoxonase-1 regulation of renal inflammation and fibrosis in chronic kidney disease
Papraoxonase-1 (PON1) is a hydrolytic lactonase enzyme that is synthesized in the liver and
circulates attached to high-density lipoproteins (HDL). Clinical studies have demonstrated …
circulates attached to high-density lipoproteins (HDL). Clinical studies have demonstrated …
Improved risk assessment of coronary artery disease by substituting paraoxonase 1 activity for HDL-C: Novel cardiometabolic biomarkers based on HDL functionality
Background and aims Develo** laboratory assays to evaluate HDL functions and improve
cardiovascular disease (CVD) risk assessment has recently emerged as a challenge. The …
cardiovascular disease (CVD) risk assessment has recently emerged as a challenge. The …