[HTML][HTML] Synthetic and natural guanidine derivatives as antitumor and antimicrobial agents: A review
AR Gomes, CL Varela, AS Pires… - Bioorganic …, 2023 - Elsevier
Guanidines are fascinating small nitrogen-rich organic compounds, which have been
frequently associated with a wide range of biological activities. This is mainly due to their …
frequently associated with a wide range of biological activities. This is mainly due to their …
Kirenol: a potential natural lead molecule for a new drug design, development, and therapy for inflammation
Kirenol, a potential natural diterpenoid molecule, is mainly found in Sigesbeckia species.
Kirenol has received a lot of interest in recent years due to its wide range of pharmacological …
Kirenol has received a lot of interest in recent years due to its wide range of pharmacological …
The isolation of water-soluble natural products–challenges, strategies and perspectives
Covering period: up to 2019 Water-soluble natural products constitute a relevant group of
secondary metabolites notably known for presenting potent biological activities. Examples …
secondary metabolites notably known for presenting potent biological activities. Examples …
Enantioselective Total Synthesis of (+)-KB343
A concise total synthesis of the complex guanidinium toxin KB343 is reported traversing
through an unusual sequence of chemoselective transformations and strategic skeletal …
through an unusual sequence of chemoselective transformations and strategic skeletal …
Structural characterization and immunomodulatory activity of an exopolysaccharide from marine-derived Aspergillus versicolor SCAU141
K Wu, Y Li, Y Lin, B Xu, J Yang, L Mo, R Huang… - International Journal of …, 2023 - Elsevier
Until now, relatively little is known about marine-derived fungal polysaccharides and their
activities. Exopolysaccharide AVP141-A was isolated from the broth of marine-derived …
activities. Exopolysaccharide AVP141-A was isolated from the broth of marine-derived …
Sponges present a core prokaryotic community stable across Tropical Western Atlantic
Sponges are among the earliest lineages of metazoans, with first fossil records dated back
to 890 million years ago. All sponge species present associations with microorganisms to …
to 890 million years ago. All sponge species present associations with microorganisms to …
Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action
D Schum, FAV Elsen, S Ruddell, K Schorpp, H Junca… - JACS Au, 2024 - ACS Publications
Screening large molecule libraries against pathogenic bacteria is often challenged by a low
hit rate due to limited uptake, underrepresentation of antibiotic structural motifs, and assays …
hit rate due to limited uptake, underrepresentation of antibiotic structural motifs, and assays …
[HTML][HTML] Structure-activity study of oncocin: On-resin guanidinylation and incorporation of homoarginine, 4-hydroxyproline or 4, 4-difluoroproline residues
Antimicrobial peptides (AMPs) often display guanidinium functionalities, and hence robust
synthetic procedures are needed to facilitate access to analogues with unnatural …
synthetic procedures are needed to facilitate access to analogues with unnatural …
Atom-economic macrocyclic amphiphile based on guanidinium-functionalized selenacrown ether acting as redox-responsive nanozyme
B Li, Q Xu, X Shen, T Pan, J Shang, Y Ge, Z Qi - Chinese Chemical Letters, 2023 - Elsevier
Control of self-assembly is significant to the preparation of supramolecular materials, but the
control of hydration, responsiveness, dimension, catalysis of macrocyclic amphiphiles in an …
control of hydration, responsiveness, dimension, catalysis of macrocyclic amphiphiles in an …
Exploring Guanidinium Organocatalysts for Hypoiodite‐Mediated Reactions
M Odagi, K Nagasawa - The Chemical Record, 2023 - Wiley Online Library
This account describes our recent work on develo** guanidinium hypoiodite‐catalysts for
oxidative carbon‐nitrogen and carbon‐carbon bond‐forming reactions. These reactions …
oxidative carbon‐nitrogen and carbon‐carbon bond‐forming reactions. These reactions …