Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

As an emerging science, tissue engineering and regenerative medicine focus on develo**
materials to replace, restore or improve organs or tissues and enhancing the cellular …

Although hydrogels have been widely studied because of their satisfactory biocompatibility
and plasticity, their application is limited in bone tissue engineering (BTE) owing to their …

The development of bone tissue engineering indicates some new paths for bone defect
repair. Mild photothermal therapy (PTT) is flourishing as an exciting potential method for …

As the main load-bearing structure in the human body, bone and cartilage are susceptible to
damage in sports and other activities. The repair and regeneration of bone and articular …

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons
worldwide. Despite the variety of surgical techniques, current clinical strategies for bone …

Background Sustained release of bioactive BMP2 (bone morphogenetic protein-2) is
important for bone regeneration, while the intrinsic short half-life of BMP2 at protein level …

Osteonecrosis of the femoral head (ONFH), a progressive pathological process of femoral
head ischemia and osteocyte necrosis, is a refractory orthopedic disease caused by multiple …

Severe bone defects can be caused by various factors, such as tumor resection, severe
trauma, and infection. However, bone regeneration capacity is limited up to a critical-size …

The electrospun fibrous scaffold has shown a great potential due to an extracellular matrix-
mimicking structure of nanofibers, however, a three-dimensional (3D) fibrous scaffold, much …