Dengue virus and the host innate immune response

N Uno, TM Ross - Emerging microbes & infections, 2018 - Taylor & Francis
Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …

Mathematical models for dengue fever epidemiology: A 10-year systematic review

M Aguiar, V Anam, KB Blyuss, CDS Estadilla… - Physics of Life …, 2022 - Elsevier
Mathematical models have a long history in epidemiological research, and as the COVID-19
pandemic progressed, research on mathematical modeling became imperative and very …

Map** global trends in vaccine confidence and investigating barriers to vaccine uptake: a large-scale retrospective temporal modelling study

A De Figueiredo, C Simas, E Karafillakis, P Paterson… - The Lancet, 2020 - thelancet.com
Background There is growing evidence of vaccine delays or refusals due to a lack of trust in
the importance, safety, or effectiveness of vaccines, alongside persisting access issues …

Challenges on the development of a dengue vaccine: a comprehensive review of the state of the art

J Pintado Silva… - Journal of General …, 2023 - microbiologyresearch.org
Dengue virus (DENV) is the mosquito-borne virus of greatest human health concern. There
are four serotypes of DENV (1-4) that co-circulate in endemic areas. Each serotype of DENV …

The impact of the newly licensed dengue vaccine in endemic countries

M Aguiar, N Stollenwerk… - PLoS neglected tropical …, 2016 - journals.plos.org
Background With approximately 3 billion people at risk of acquiring the infection, dengue
fever is now considered the most important mosquito-borne viral disease in the world, with …

Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis

HY Chong, CY Leow, ABA Majeed, CH Leow - Virus research, 2019 - Elsevier
Flaviviruses are group of single stranded RNA viruses that cause severe endemic infection
and epidemics on a global scale. It presents a significant health impact worldwide and the …

Milk exosomes elicit a potent anti-viral activity against dengue virus

VR Yenuganti, S Afroz, RA Khan, C Bharadwaj… - Journal of …, 2022 - Springer
Background Exosomes are nano-sized vesicles secreted by various cells into the intra and
extracellular space and hence is an integral part of biological fluids including milk. In the last …

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication

CMD Swarbrick, C Basavannacharya… - Nucleic acids …, 2017 - academic.oup.com
The protein–RNA interactions within the flavivirus replication complex (RC) are not fully
understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase …

Critical fluctuations in epidemic models explain COVID-19 post-lockdown dynamics

M Aguiar, JB Van-Dierdonck, J Mar, N Cusimano… - Scientific Reports, 2021 - nature.com
As the COVID-19 pandemic progressed, research on mathematical modeling became
imperative and very influential to understand the epidemiological dynamics of disease …

Vitamin D-mediated attenuation of miR-155 in human macrophages infected with dengue virus: Implications for the cytokine response

JF Arboleda, GJ Fernandez… - Infection, Genetics and …, 2019 - Elsevier
Clinical manifestations of dengue disease rely on complex interactions between dengue
virus (DENV) and host factors that drive altered immune responses, including excessive …