Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to
external cues to regulate the many uses of DNA. A principle component of chromatin that …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Summary N 6-methyladenosine (m 6 A) is the most prevalent internal modification of
messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …

Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight
different classes have been characterized to date and many different sites have been …

IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading
to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2 …