Designing bioresponsive nanomaterials for intracellular self-assembly
Supramolecular assemblies are essential components of living organisms. Cellular
scaffolds, such as the cytoskeleton or the cell membrane, are formed via secondary …
scaffolds, such as the cytoskeleton or the cell membrane, are formed via secondary …
The role of thiols in antioxidant systems
The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …
specialized and unique features that enable them to serve a variety of different functions in …
Chemical Biology of H2S Signaling through Persulfidation
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …
inducible expression of a battery of genes encoding key components of the glutathione …
[HTML][HTML] A quantitative tissue-specific landscape of protein redox regulation during aging
Mammalian tissues engage in specialized physiology that is regulated through reversible
modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a …
modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a …
Redox signaling by reactive electrophiles and oxidants
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
3-Mercaptopyruvate sulfur transferase is a protein persulfidase
Abstract Protein S-persulfidation (P-SSH) is recognized as a common posttranslational
modification. It occurs under basal conditions and is often observed to be elevated under …
modification. It occurs under basal conditions and is often observed to be elevated under …
The role of oxidative stress in Parkinson's disease
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …
Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?
Duality of iron as an essential cofactor of many enzymatic metabolic processes and as a
catalyst of poorly controlled redox-cycling reactions defines its possible biological beneficial …
catalyst of poorly controlled redox-cycling reactions defines its possible biological beneficial …
Effects of ionizing radiation on biological molecules—mechanisms of damage and emerging methods of detection
Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …
series of events that are amplified by endogenous signaling and culminating in oxidative …