Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

Checkpoint inhibition immunotherapy has revolutionized cancer treatment, but many
patients show resistance. Here we perform integrative transcriptomic and proteomic …

Advances in melanoma research have unveiled critical insights into its genetic and
molecular landscape, leading to significant therapeutic innovations. This review explores the …

Simple Summary A bottleneck in oncology is the translation of results from preclinical
models to the clinics. The rate of anticancer drugs that are effective in preclinical studies but …

Emerging nanotechnologies demonstrate unparalleled benefits in expediting cancer
treatment. Despite the widespread use of nanocomposites in tumor therapy, particularly in …

A pervasive view is that undifferentiated stem cells are alone responsible for generating all
other cells and are the origins of cancer. However, emerging evidence demonstrates fully …

Abstract/outline The field of high content imaging has steadily evolved and expanded
substantially across many industry and academic research institutions since it was first …

Novel therapeutic strategies are needed to improve the efficacy of chimeric antigen receptor
(CAR) T cells as a treatment of solid tumors. Multiple tumor microenvironmental factors are …

Small nucleotide variants in non-coding regions of the genome can alter transcriptional
regulation, leading to changes in gene expression which can activate oncogenic gene …