[HTML][HTML] Preparation and use of decellularized extracellular matrix for tissue engineering

AD McInnes, MAJ Moser, X Chen - Journal of functional biomaterials, 2022 - mdpi.com
The multidisciplinary fields of tissue engineering and regenerative medicine have the
potential to revolutionize the practise of medicine through the abilities to repair, regenerate …

Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells

TY Lu, B Lin, J Kim, M Sullivan, K Tobita… - Nature …, 2013 - nature.com
Heart disease is the leading cause of death in the world. Heart tissue engineering holds a
great promise for future heart disease therapy by building personalized heart tissues. Here …

Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit map** and phenoty**

JB Treweek, KY Chan, NC Flytzanis, B Yang… - Nature protocols, 2015 - nature.com
To facilitate fine-scale phenoty** of whole specimens, we describe here a set of tissue
fixation-embedding, detergent-clearing and staining protocols that can be used to transform …

[HTML][HTML] Recellularization of native tissue derived acellular scaffolds with mesenchymal stem cells

E Ahmed, T Saleh, M Xu - Cells, 2021 - mdpi.com
The functionalization of decellularized scaffolds is still challenging because of the
recellularization-related limitations, including the finding of the most optimal kind of cell (s) …

Proteomic analysis of naturally-sourced biological scaffolds

Q Li, BE Uygun, S Geerts, S Ozer, M Scalf, SE Gilpin… - Biomaterials, 2016 - Elsevier
A key challenge to the clinical implementation of decellularized scaffold-based tissue
engineering lies in understanding the process of removing cells and immunogenic material …

[HTML][HTML] Perfusion-decellularization of human ear grafts enables ECM-based scaffolds for auricular vascularized composite tissue engineering

J Duisit, H Amiel, T Wüthrich, A Taddeo, A Dedriche… - Acta biomaterialia, 2018 - Elsevier
Introduction: Human ear reconstruction is recognized as the emblematic enterprise in tissue
engineering. Up to now, it has failed to reach human applications requiring appropriate …

Application of whole-organ tissue engineering in hepatology

BE Uygun, ML Yarmush, K Uygun - Nature reviews Gastroenterology & …, 2012 - nature.com
Initially hailed as the ultimate solution to organ failure, engineering of vascularized tissues
such as the liver has stalled because of the need for a well-structured circulatory system that …

A decellularization methodology for the production of a natural acellular intestinal matrix

P Maghsoudlou, G Totonelli… - Journal of …, 2013 - pmc.ncbi.nlm.nih.gov
Successful tissue engineering involves the combination of scaffolds with appropriate cells in
vitro or in vivo. Scaffolds may be synthetic, naturally-derived or derived from tissues/organs …

Nondestructive methods for monitoring cell removal during rat liver decellularization

S Geerts, S Ozer, M Jaramillo, ML Yarmush… - … Engineering Part C …, 2016 - liebertpub.com
Whole liver engineering holds the promise to create transplantable liver grafts that may
serve as substitutes for donor organs, addressing the donor shortage in liver transplantation …

[HTML][HTML] Human-origin iPSC-based recellularization of decellularized whole rat livers

A Acun, R Oganesyan, M Jaramillo, ML Yarmush… - Bioengineering, 2022 - mdpi.com
End-stage liver diseases lead to mortality of millions of patients, as the only treatment
available is liver transplantation and donor scarcity means that patients have to wait long …