Fluorescent analogs of biomolecular building blocks: design, properties, and applications

RW Sinkeldam, NJ Greco, Y Tor - Chemical reviews, 2010‏ - ACS Publications
Fluorescence spectroscopy, one of the most informative and sensitive analytical techniques,
has played and continues to play key roles in modern research. Indeed, unraveling the inner …

Fundamental photophysics of isomorphic and expanded fluorescent nucleoside analogues

D Dziuba, P Didier, S Ciaco, A Barth… - Chemical Society …, 2021‏ - pubs.rsc.org
Fluorescent nucleoside analogues (FNAs) are structurally diverse mimics of the natural
essentially non-fluorescent nucleosides which have found numerous applications in probing …

Emissive nucleosides as molecular rotors

RW Sinkeldam, AJ Wheat, H Boyaci… - … : a European journal of …, 2010‏ - pmc.ncbi.nlm.nih.gov
D-ribose moiety. The structural features of nucleosides and their corresponding nucleotides
are context-dependent and are largely dictated by two major and distinct “degrees” of …

Structural and mechanistic basis for a new mode of glycosyltransferase inhibition

T Pesnot, R Jørgensen, MM Palcic… - Nature chemical …, 2010‏ - nature.com
Glycosyltransferases are carbohydrate-active enzymes with essential roles in numerous
important biological processes. We have developed a new donor analog for …

DNA abasic site-directed formation of fluorescent silver nanoclusters for selectivenucleobase recognition

K Ma, Q Cui, G Liu, F Wu, S Xu, Y Shao - Nanotechnology, 2011‏ - iopscience.iop.org
DNA single-nucleotide polymorphism (SNP) detection has attracted much attention due to
mutation related diseases. Various methods for SNP detection have been proposed and …

A simple molecular rotor for defining nucleoside environment within a DNA aptamer–protein complex

TZ Cservenyi, AJ Van Riesen, FD Berger… - ACS chemical …, 2016‏ - ACS Publications
The simple 5-furyl-2′-deoxyuridine (FurdU) nucleobase exhibits dual probing
characteristics displaying emissive sensitivity to changes in microenvironment polarity and …

Unveiling structural and energetic characterization of the emissive RNA alphabet anchored in the methylthieno [3, 4-d] pyrimidine heterocycle core

M Chawla, A Poater, R Oliva, L Cavallo - Physical Chemistry Chemical …, 2024‏ - pubs.rsc.org
This study presents a comprehensive theoretical exploration of the fluorescent non-natural
emissive nucleobases-mthA, mthG, mthC, and mthU derived from the methylthieno [3, 4-d] …

An emissive C analog distinguishes between G, 8-oxoG, and T

NJ Greco, RW Sinkeldam, Y Tor - Organic letters, 2009‏ - ACS Publications
An Emissive C Analog Distinguishes between G, 8-oxoG, and T | Organic Letters Recently
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Enzymatic incorporation of an azide-modified UTP analog into oligoribonucleotides for post-transcriptional chemical functionalization

H Rao, AA Tanpure, AA Sawant, SG Srivatsan - nature protocols, 2012‏ - nature.com
This protocol describes the detailed experimental procedure for the synthesis of an azide-
modified uridine triphosphate analog and its effective incorporation into an …

[كتاب][B] Methods for studying nucleic acid/drug interactions

M Wanunu, Y Tor - 2011‏ - books.google.com
Since most therapeutic efforts have been predominantly focused on pharmaceuticals that
target proteins, there is an unmet need to develop drugs that intercept cellular pathways that …