The enhanced permeability and retention (EPR) effect: the significance of the concept and methods to enhance its application

J Wu - Journal of personalized medicine, 2021 - mdpi.com
Chemotherapy for human solid tumors in clinical practice is far from satisfactory. Despite the
discovery and synthesis of hundreds of thousands of anticancer compounds targeting …

Ultrasound and nanomaterial: an efficient pair to fight cancer

E Alphandéry - Journal of Nanobiotechnology, 2022 - Springer
Ultrasounds are often used in cancer treatment protocols, eg to collect tumor tissues in the
right location using ultrasound-guided biopsy, to image the region of the tumor using more …

Immunogene therapy with fusogenic nanoparticles modulates macrophage response to Staphylococcus aureus

B Kim, HB Pang, J Kang, JH Park, E Ruoslahti… - Nature …, 2018 - nature.com
The incidence of adverse effects and pathogen resistance encountered with small molecule
antibiotics is increasing. As such, there is mounting focus on immunogene therapy to …

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

MA Farooq, M Aquib, A Farooq… - Artificial cells …, 2019 - Taylor & Francis
Abstract Cisplatin cis-(diammine) dichloridoplatinum (II)(CDDP) is the first platinum-based
complex approved by the food and drug administration (FDA) of the United States (US) …

PEGylated nanocarriers: A promising tool for targeted delivery to the brain

KR Gajbhiye, A Pawar, KR Mahadik… - Colloids and Surfaces B …, 2020 - Elsevier
Targeted drug delivery across the blood–brain barrier is an extremely challenging quest in
the fight with fatal brain ailments, with the major hurdles being short circulation time …

Physicochemical study of the protein–liposome interactions: Influence of liposome composition and concentration on protein binding

P Foteini, N Pippa, N Naziris… - Journal of liposome …, 2019 - Taylor & Francis
The aim of the present study is to investigate the interactions between liposomes and
proteins and to evaluate the role of liposomal lipid composition and concentration in the …

Cisplatin uptake and release assessment from hydrogel synthesized in acidic and neutral medium: An experimental and molecular dynamics simulation study

I Salahshoori, Z Ramezani, I Cacciotti… - Journal of Molecular …, 2021 - Elsevier
Targeted drug delivery systems (TDDS) are currently considered to overcome traditional
drug delivery systems' criticisms and weaknesses. Biodegradable hydrogels are widely …

Co-encapsulation of fisetin and cisplatin into liposomes for glioma therapy: from formulation to cell evaluation

M Renault-Mahieux, V Vieillard, J Seguin, P Espeau… - Pharmaceutics, 2021 - mdpi.com
(1) Background: Glioblastoma (GBM) is the most frequent cerebral tumor. It almost always
relapses and there is no validated treatment for second-line GBM. We proposed the …

Synergistic antitumor efficacy mediated by liposomal co-delivery of polymeric micelles of vinorelbine and cisplatin in non-small cell lung cancer

S Wang, J Gou, Y Wang, X Tan, L Zhao… - International journal …, 2021 - Taylor & Francis
Purpose Non-small cell lung cancer (NSCLC) is an aggressive tumor with high mortality and
poor prognosis. In this study, we designed a liposome encapsulating polymeric micelles …

Facial Amphiphile-Modified Lipids Highly Sensitize Liposomes toward Secretory Phospholipase A2

Y Liu, X Yao, C Wen, D Li, J Zhang, B **… - Molecular …, 2024 - ACS Publications
Upregulated secretory phospholipase A2 (sPLA2) in tumors has been proposed as a
stimulus to trigger drug release from liposomes for therapeutic effects. However, the current …