Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
About 10 distinct potassium channels in the heart are involved in sha** the action
potential. Some of the K+ channels are primarily responsible for early repolarization …
potential. Some of the K+ channels are primarily responsible for early repolarization …
Pharmacology of small-and intermediate-conductance calcium-activated potassium channels
BM Brown, H Shim, P Christophersen… - Annual review of …, 2020 - annualreviews.org
The three small-conductance calcium-activated potassium (KCa2) channels and the related
intermediate-conductance KCa3. 1 channel are voltage-independent K+ channels that …
intermediate-conductance KCa3. 1 channel are voltage-independent K+ channels that …
Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation
Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria
Aims Small-conductance calcium-activated potassium (SK) channels are expressed in the
heart of various species, including humans. The aim of the present study was to address …
heart of various species, including humans. The aim of the present study was to address …
Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog
XY Qi, JG Diness, BJJM Brundel, XB Zhou, P Naud… - Circulation, 2014 - Am Heart Assoc
Background—Recent evidence points to functional Ca2+-dependent K+ (SK) channels in
the heart that may govern atrial fibrillation (AF) risk, but the underlying mechanisms are …
the heart that may govern atrial fibrillation (AF) risk, but the underlying mechanisms are …
Regulation of the SK3 channel by microRNA-499—potential role in atrial fibrillation
TY Ling, XL Wang, Q Chai, TW Lau, CM Koestler… - Heart Rhythm, 2013 - Elsevier
BACKGROUND: MicroRNAs are important regulators of gene expression, including those
involving electrical remodeling in atrial fibrillation (AF). Recently, KCNN3, the gene that …
involving electrical remodeling in atrial fibrillation (AF). Recently, KCNN3, the gene that …
Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics
N Chiamvimonvat, Y Chen‐Izu… - The Journal of …, 2017 - Wiley Online Library
This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …
[HTML][HTML] Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease
Atrial fibrillation (AF) is prevalent in common conditions and acquired forms of heart disease,
including diabetes mellitus (DM), hypertension, cardiac hypertrophy, and heart failure. AF is …
including diabetes mellitus (DM), hypertension, cardiac hypertrophy, and heart failure. AF is …
Cardiac small-conductance calcium-activated potassium channels in health and disease
Abstract Small-conductance Ca 2+-activated K+(SK, K Ca 2) channels are encoded by
KCNN genes, including KCNN 1, 2, and 3. The channels play critical roles in the regulation …
KCNN genes, including KCNN 1, 2, and 3. The channels play critical roles in the regulation …
Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing
Background Both ageing and hypertension are known risk factors for atrial fibrillation (AF)
although the pathophysiological contribution or interaction of the individual factors remains …
although the pathophysiological contribution or interaction of the individual factors remains …