Signature Cytokines and Immune-Mediated Inflammatory Diseases The ability to block
specific cytokine pathways has revealed pathophysiological differences among autoimmune …

Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the
high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of …

Spondyloarthritis (SpA) comprises a group of chronic inflammatory diseases with
overlap** clinical, genetic and pathophysiological features including back pain, peripheral …

Over the recent years the wider availability and application of state-of-the-art immunological
technologies greatly advanced the insight into the mechanisms that play an important role in …

Objectives Increasing evidence suggests that inflammatory mechanisms play a key role in
chronic tendon disease. After observing T cell signatures in human tendinopathy, we …

Spondyloarthritis (SpA) is characterized by the infiltration of innate and adaptive immune
cells into entheses and bone marrow. Molecular, cellular and imaging evidence …

Abstract The IL-23/IL-17 cytokine axis is related to spondyloarthropathy (SpA) pattern
diseases that target the skin, eye, gut and joints. These share overlap** target tissues with …

Spondyloarthritis and inflammatory bowel diseases are chronic immune disorders of the
joints and the gut that often coexist in the same patient, increasing the burden of each …