Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions

P Lu, D Ruan, M Huang, M Tian, K Zhu… - Signal transduction and …, 2024 - nature.com
The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

H Yu, R Gao, Y Liu, L Fu, J Zhou, L Li - Advanced Science, 2024 - Wiley Online Library
Deregulated inflammations induced by various factors are one of the most common
diseases in people's daily life, while severe inflammation can even lead to death. Thus, the …

Mimicking antioxidases and hyaluronan synthase: a zwitterionic nanozyme for photothermal therapy of osteoarthritis

P Yu, Y Li, H Sun, H Zhang, H Kang, P Wang… - Advanced …, 2023 - Wiley Online Library
Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are
limited to unilateral efforts in joint lubrication, inhibition of inflammation, free radicals …

Bio-inspired anisotropic hydrogels and their applications in soft actuators and robots

Z Chen, H Wang, Y Cao, Y Chen, O Akkus, H Liu… - Matter, 2023 - cell.com
Hydrogels offer great potential for the development of soft actuators and robots owing to their
water-rich structures, remarkable biocompatibility, and responsiveness to various stimuli …

Calcitriol-loaded multifunctional nanospheres with superlubricity for advanced osteoarthritis treatment

C **e, Q Sun, Y Dong, H Lu, W Li, Z Lin, K Li, J Cheng… - ACS …, 2023 - ACS Publications
Osteoarthritis (OA) is characterized by the lubrication dysfunction of a cartilage sliding
interface caused by chronic joint inflammation, and effective nonsurgical therapy for …

Hypoxia and matrix metalloproteinase 13‐responsive hydrogel microspheres alleviate osteoarthritis progression in vivo

T Zhou, H **ong, SY Yao, S Wang, S Li, J Chang… - Small, 2024 - Wiley Online Library
The occurrence of osteoarthritis (OA) is highly associated with the inflammatory hypoxic
microenvironment. Yet currently no attention has been paid to fabricating hypoxia …

Hydrogels for ameliorating osteoarthritis: mechanical modulation, anti‐inflammation, and regeneration

X Jiang, Y Sun, Y Lyu, H Kang, J Zhao, K Zhang… - …, 2024 - Wiley Online Library
Osteoarthritis (OA) is a chronic and degenerative disease with limited clinical options for
effective suppression. Recently, significant endeavors have been explored to reveal its …

The lubricated matter in body

H Yuan, W Cui - Progress in Materials Science, 2024 - Elsevier
Lubrication is everywhere in the body and essential for the correct operation of biological
systems when subjected to contact stress and wear. The body is like a continuously …

Inspired by lubricin: a tailored cartilage-armor with durable lubricity and autophagy-activated antioxidation for targeted therapy of osteoarthritis

P Yu, X Peng, H Sun, Q **n, H Kang, P Wang… - Materials …, 2024 - pubs.rsc.org
Osteoarthritis (OA), which disables articular cartilage, affects millions of people. The self-
healing capacity is inhibited by internal oxidative stress and external lubrication deficiency …

Recent research progress of hydrogel on cartilage

Q Ma, D Lin, Y Liu, X Liu, H Zhao, G Zhou, S Liu… - European Polymer …, 2024 - Elsevier
The articular cartilage (AC) is a dense, translucent, and avascular connective tissue
primarily responsible for bearing the load of normal human activities. Due to its lack of blood …