NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …

The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

The NF-κB transcription factor is the master regulator of the inflammatory response and is
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …

Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …

The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of
macrophages, which may impact the development of atherosclerosis. Changes in Akt …

A properly mounted immune response is indispensable for recognizing and eliminating
danger arising from foreign invaders and tissue trauma. However, the'inflammatory …

Recent studies have indicated that the regulation of innate immunity and energy metabolism
are connected together through an antagonistic crosstalk between NF-κB and SIRT1 …

NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …