Extracellular biophysical properties have particular implications for a wide spectrum of
cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …

Visualization of biomedical samples in their native environments at the microscopic scale is
crucial for studying fundamental principles and discovering biomedical systems with …

Neurodegeneration poses a significant challenge for the fields of neuroscience and
medicine, as it is the underlying cause of the development and advancement of numerous …

Immunotherapy based on immune checkpoint inhibitors has evolved into a new pillar of
cancer treatment in clinics, but dealing with treatment resistance (either primary or acquired) …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …

Notch signaling pathway is evolutionarily conserved in mammals, which plays an important
role in cell development and differentiation. In recent years, increasing evidence has shown …

Stain-free, single-cell segmentation and tracking is tantamount to the holy grail of
microscopic cell migration analysis. Phase contrast microscopy (PCM) images with cells at …

Breast cancer is the most prevalent malignancy and the most significant contributor to
mortality in female oncology patients. Potassium Two Pore Domain Channel Subfamily K …

Over the past years, it has become evident that cancer initiation and progression depends
on several components of the tumor microenvironment, including inflammatory and immune …