The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Gut microbial metabolites as multi-kingdom intermediates

KA Krautkramer, J Fan, F Bäckhed - Nature Reviews Microbiology, 2021 - nature.com
The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

C Franceschi, P Garagnani, P Parini… - Nature Reviews …, 2018 - nature.com
Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

You are what you eat: diet, health and the gut microbiota

N Zmora, J Suez, E Elinav - Nature reviews Gastroenterology & …, 2019 - nature.com
Since the renaissance of microbiome research in the past decade, much insight has
accumulated in comprehending forces sha** the architecture and functionality of resident …

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

J Aron-Wisnewsky, C Vigliotti, J Witjes, P Le… - Nature Reviews …, 2020 - nature.com
Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes
mellitus, two metabolic diseases strongly intertwined with non-alcoholic fatty liver disease …

The gut microbiome and metabolic syndrome

K Dabke, G Hendrick, S Devkota - The Journal of clinical …, 2019 - Am Soc Clin Investig
The metabolic syndrome (MetS) is a constellation of risk factors that, if left untreated, will
often progress to greater metabolic defects such as type 2 diabetes and nonalcoholic fatty …

Microbiota succession throughout life from the cradle to the grave

C Martino, AH Dilmore, ZM Burcham… - Nature Reviews …, 2022 - nature.com
Associations between age and the human microbiota are robust and reproducible. The
microbial composition at several body sites can predict human chronological age relatively …

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

PD Cani, WM de Vos - Frontiers in microbiology, 2017 - frontiersin.org
Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide
epidemic. Among the different environmental factors, the gut microbiota is now considered …

The resilience of the intestinal microbiota influences health and disease

F Sommer, JM Anderson, R Bharti, J Raes… - Nature Reviews …, 2017 - nature.com
The composition of the intestinal microbiota varies among individuals and throughout
development, and is dependent on host and environmental factors. However, although the …

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

CA Thaiss, M Levy, I Grosheva, D Zheng, E Soffer… - Science, 2018 - science.org
Obesity, diabetes, and related manifestations are associated with an enhanced, but poorly
understood, risk for mucosal infection and systemic inflammation. Here, we show in mouse …